首页|Effect of Immune No.2(免疫2号方)on the Immune Reconstitution in Patients with HIV/AIDS after Highly Active Antiretroviral Treatment: A Randomized Double Blind Placebo Controlled Clinical Trial
Effect of Immune No.2(免疫2号方)on the Immune Reconstitution in Patients with HIV/AIDS after Highly Active Antiretroviral Treatment: A Randomized Double Blind Placebo Controlled Clinical Trial
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To observe the Immune No.2 (免疫2号方) on the immune reconstitution in patients with human immunodeficiency virus or acquired immune deficiency syndrome (HIV/AIDS) after highly active antiretroviral therapy (HAART).Methods:A randomized,double-blind,placebo-controlled clinical trial was designed.233 patients failing immune reconstitution after HAART were randomly divided into treatment group (116 cases) and control group (117 cases),respectively using Immune No.2 plus HAART and placebo combined with HAART for 6 months.CD4,CD45RA,CD45RO cell numbers,as well as the symptoms,signs and integral improvement rates were observed in order to evaluate the immune reconstitution efficiency.Results:after the intervention for 1month,the effective rate of the treatment group (18.97％,22/116) was significantly higher than that of the control group (9.40％,11/117) (P=0.02); 3 months after treatment,the effective rate of the treatment group (27.59％,32/116) was no difference from that of the control group (22.22％,26/117) (P=0.31); 6 months after treatment,the effective rate of the treatment group (34.48％,40/116) was significantly superior to the control group (21.37％,25/117) (P=0.02).CD4,CD45RA,CD45RO count of the treatment group was significantly higher than that of the control group (P＜0.05).The total score of symptoms and signs in the treatment group was significantly lowered compared with the control group (P=0.02),and the improvement of fatigue,muscle and joint pain,pruritus and shortness of breath in the treatment group was better than the control group (P＜0.05).Conclusion:Immune No.2 can effectively improve the numbers of CD4 cells and its subgroups,as well as the main clinical symptoms and signs of patients after HAART,thereby promoting the immune reconstitution.
HIV/AIDSimmune reconstitutionImmune No.2
WANG Jie、LI Yong、TANG Yan-li、LIN Hong-sheng、WU Xin-fang、LIU Jie
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Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053 , China
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