首页|Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.

Chinese medicinepolysaccharidesgut microbiotashort-chain fatty acidslipopolysaccharidesgut-organ axissynergistic actions

ZHAO Wen-xiao、WANG Tong、ZHANG Ya-nan、CHEN Qian、WANG Yuan、XING Yan-qing、ZHENG Jun、DUAN Chen-chen、CHEN Li-jun、ZHAO Hai-jun、WANG Shi-jun

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School of Nursing,Shandong University of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji'nan(250355),China

Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula,Shandong University of Traditional Chinese Medicine,Ji'nan(250355),China

College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji'nan(250355),China

National Natural Science Foundation of ChinaKey Research and Development Project of Shandong Province,ChinaKey Basic Research of the Natural Science Foundation of Shandong Province,ChinaShandong University Youth Innovative Talent Introduction ProjectShandong University Youth Innovative Talent Introduction Project

819039472019GSF108209ZR2019ZD23LJRZ 20199-201

2024

10.1007/s11655-022-3522-y

中国结合医学杂志(英文版)
中国中西医结合学会 中国中医研究院

中国结合医学杂志(英文版)

CSTPCD
影响因子：1.056
ISSN：1672-0415
年,卷(期)：2024.30(2)
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