首页|Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human health.Lipoprotein-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to AS.Lp-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(oxPC)to produce lysophosphatidylcholine(lysoPC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability.This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

lipoprotein-associated phospholipase A2atherosclerosisinflammationoxidative stressapoptosisChinese medicine

WANG Lu-ming、ZHANG Wen-Ian、LYU Nuan、SUO Yan-rong、YANG Lin、YU Bin、JIANG Xi-juan

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School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin(301617),China

Department of Traditional Chinese Medicine,Ganzhou People's Hospital,Ganzhou,Jiangxi Province(341000),China

School of Medical Technology,Tianjin University of Traditional Chinese Medicine,Tianjin(301617),China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaGraduate Research Innovation Project of Tianjin University of Traditional Chinese MedicineGraduate Research Innovation Project of Tianjin University of Traditional Chinese Medicine2021 Annual Graduate Students Innovation Fund of School of Integrative Medicine,Tianjin University of Traditional Chinese Medici2021 Annual Graduate Students Innovation Fund of School of Integrative Medicine,Tianjin University of Traditional Chinese Medici

82074211818731308216140470YJSKC-20221026YJSKC-20221029ZXYCXLX202116ZXYCXLX202101

2024

10.1007/s11655-023-3611-6

中国结合医学杂志(英文版)
中国中西医结合学会 中国中医研究院

中国结合医学杂志(英文版)

CSTPCD
影响因子：1.056
ISSN：1672-0415
年,卷(期)：2024.30(3)
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