首页|Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety:The ADECODE-Real World Study

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety:The ADECODE-Real World Study

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Objective:To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP)in treating anxiety and depression in patients with coronary heart disease(CHD).Methods:A total of 1,428 patients diagnosed with CHD screened for anxiety,depression,and quality of life(QOL)at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment.Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7),Patient Health Questionnaire-9(PHQ-9),and Seattle Angina Questionnaire(SAQ)for evaluating anxiety,depression,and QOL.Patients were followed up 3 times,once every 4 weeks,during outpatient visits for 12 weeks.Results:At the third follow-up(F3),the anxiety symptom of 63.79％(673/1,055)of the patients improved to sub-clinical level,and the GAD-7 score improved significantly(8.11 vs.3.87,P＜0.01);57.52％(585/1,017)patients'depressive symptoms improved to sub-clinical level,with a significant improvement in PHQ-9 score(8.69 vs.4.41,P＜0.01)at F3.All aspects of QOL significantly improved at the end of treatment compared to those at baseline(all P＜0.01)as assessed by SAQ:physical limitation(31.17 vs.34.14),anginal stability(2.74 vs.4.14),anginal frequency(8.16 vs.9.10),treatment satisfaction(13.43 vs.16.29),and disease perception(8.69 vs.11.02).Conclusions:A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No.ChiCTR2100051523)

Guanxin Danshen Dripping Pillcoronary heart diseasedepressionanxietyquality of lifeChinese medicine

WU Shi-hao、SHI Wei-qi、LI Yu-hang、LIU Ru-hui、HU Da-yi、ZHENG Li-qiang、MA Wen-lin

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Department of Geriatric Medicine,Tongji Hospital,School of Medicine,Tongji University,Shanghai(200065),China

Department of Cardiology,Tongji Hospital,School of Medicine,Tongji University,Shanghai(200065),China

Department of Cardiology,Peking University People's Hospital,Beijing(100044),China

School of Public Health,Shanghai Jiao Tong University,Shanghai(200030),China

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National Administration of Traditional Chinese Medicine

2016ZX04

2024

10.1007/s11655-023-3628-x

中国结合医学杂志(英文版)
中国中西医结合学会 中国中医研究院

中国结合医学杂志(英文版)

CSTPCD
影响因子：1.056
ISSN：1672-0415
年,卷(期)：2024.30(5)
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