首页|Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(ncRNAs)are important regulatory factors.Many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4-NF-κ B signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

pyroptosiscardiovascular diseasesChinese medicineNOD-like receptor protein 3mechanisms

ZHONG Yi、LI Xin-yue、LIANG Tian-jun、DING Bao-zhu、MA Ke-xin、REN Wen-xuan、LIANG Wen-jie

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College of Integrated Traditional Chinese and Western Medicine,Hebei University of Chinese Medicine,Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney Diseases,Institute of Integrated Traditional Chinese and Western Medicine,Shijiazhuang(050200),China

Department of Cardiovascular Internal Medicine,the Second Affiliated Hospital of Jiujiang University,Jiujiang,Jiangxi Province(332000),China

Graduate School,Hebei Medical University,Shijiazhuang(050017),China

Rural Physician College,Hebei Medical University,Shijiazhuang(050017),China

Medical Department,the First Hospital of Hebei Medical University,Shijiazhuang(050030),China

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Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine

2020149

2024

10.1007/s11655-024-3655-2

中国结合医学杂志(英文版)
中国中西医结合学会 中国中医研究院

中国结合医学杂志(英文版)

CSTPCD
影响因子：1.056
ISSN：1672-0415
年,卷(期)：2024.30(5)
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