首页|Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
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Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis.They can adopt two distinct phenotypes,primarily determined by environmental cues.These phenotypes encompass the classically activated pro-inflammatory M1 phenotype,as well as the alternatively activated anti-inflammatory M2 phenotype.In regular conditions,intestinal macrophages serve to shield the gut from inflammatory harm.However,when a combination of genetic and environmental elements influences the polarization of these macrophages,it can result in an M1/M2 macrophage activation imbalance,subsequently leading to a loss of control over intestinal inflammation.This shift transforms normal inflammatory responses into pathological damage within the intestines.In patients with ulcerative colitis-associated colorectal cancer(UC-CRC),disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages.Therefore,reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC.This paper aims to scrutinize the clinical evidence regarding Chinese medicine(CM)in the treatment of UC-CRC,the pivotal role of macrophage polarization in UC-CRC pathogenesis,and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC.Our objective is to offer fresh perspectives for clinical application,fundamental research,and pharmaceutical advancement in UC-CRC.
macrophageulcerative colitiscolon cancerChinese medicine
School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou(510006),China
Department of Surgery Ⅱ,Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Gaozhou(525200),China
Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou(510405),China
The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou(510405),China
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国家自然科学基金Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese MedicineScience and Technology Innovation Special Topic of Maoming CityScience and Technology Innovation Special Topic of Maoming CityScience and Technology Innovation Special Topic of Maoming CityScience and Technology Innovation Special Topic of Maoming City
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