首页|Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache:A Secondary Analysis of A Randomized Controlled Trial
Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache:A Secondary Analysis of A Randomized Controlled Trial
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Objective:To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache(CTTH).Methods:Using data from the randomized clinical trial(218 cases)consisting of 4 weeks of baseline assessment,8 weeks of treatment,and 24 weeks of follow-up,participants were regrouped into responders(at least a 50%reduction in monthly headache days at week 16 compared with baseline)and non-responders.Twenty-three demographic and disease-related factors associated with acupuncture response in 183 participants were analyzed by multivariable logistic regression.Results:One hundred and nineteen(65.0%)participants were classified as responders.Four factors were significantly independently associated with acupuncture response,including treatment assignment,headache intensity at baseline,and 2 domains[general health(GH)and social functioning(SF)]from the 36-Item Short Form Health Survey quality of life questionnaire.Treatment assignment was associated with non-response:participants receiving true acupuncture were 3-time more likely to achieve a CTTH response than those receiving superficial acupuncture[odds ratio(OR)0.322,95% confidence interval(CI)0.162 to 0.625,P=0.001].Compared with patients with mild-intensity headache,patients with moderate-intensity headache were twice as likely to respond to acupuncture(OR 2.001,95% CI 1.020 to 4.011,P=0.046).The likelihood of non-response increased by 4.5%with each unit increase in the GH grade(OR 0.955,95% CI 0.917 to 0.993,P=0.024)while decreased by 3.8% with each unit increase in the SF grade(OR 1.038,95% CI 1.009 to 1.069,P=0.011).Conclusions:Greater headache intensity,lower GH score,and higher SF score were associated with better acupuncture responses in CTTH patients.These 3 factors require independent validation as predictors of acupuncture effectiveness in CTTH.
acupuncturechronic tension-type headachelogistic regressionquality of lifeChinese medicine