From Perspective of Hippocampal Plasticity:Function of Antidepressant Chinese Medicine Xiaoyaosan

扫码查看

原文链接

万方数据
维普

外文摘要：The hippocampus is one of the most commonly studied brain regions in the context of depression.The volume of the hippocampus is significantly reduced in patients with depression,which severely disrupts hippocampal neuroplasticity.However,antidepressant therapies that target hippocampal neuroplasticity have not been identified as yet.Chinese medicine(CM)can slow the progression of depression,potentially by modulating hippocampal neuroplasticity.Xiaoyaosan(XYS)is a CM formula that has been clinically used for the treatment of depression.It is known to protect Gan(Liver)and Pi(Spleen)function,and may exert its antidepressant effects by regulating hippocampal neuroplasticity.In this review,we have summarized the association between depression and aberrant hippocampal neuroplasticity.Furthermore,we have discussed the researches published in the last 30 years on the effects of XYS on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against depression.The results of this review can aid future research on XYS for the treatment of depression.

外文关键词：

depressionhippocampal neuroplasticityXiaoyaosanChinese medicine

作者：

ZHANG Wu-jing、GUO Ze-xuan、WANG Yi-di、FANG Shao-yi、WAN Chun-miao、YU Xiao-long、GUO Xiao-fang、CHEN Yue-yue、ZHOU Xuan、HUANG Jun-qing、LI Xiao-juan、CHEN Jia-xu、FAN Li-li

展开 >

作者单位：

Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China

基金：

National Natural Science Foundation of ChinaJinan University Innovation and Entrepreneurship Training Program for UndergraduateJinan University Innovation and Entrepreneurship Training Program for Undergraduate

项目编号：

82304746CX21255CX22481

出版年：

2024

DOI：

10.1007/s11655-024-3908-0

中国结合医学杂志(英文版)

中国中西医结合学会中国中医研究院

中国结合医学杂志(英文版)

CSTPCD

影响因子：1.056

ISSN：1672-0415

年,卷(期)：2024.30(8)