首页|Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma

Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma

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Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the world.The treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is high.This paper reviews the range of effects of natural medicinal plant active ingredients(NMPAIs)on OSCC cancer,including the types of NMPAIs,anti-cancer mechanisms,involved signaling pathways,and clinical trials.The NMPAIs include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile oils.These active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer effects.The mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/Keap1.Clinically,NMPAIs can inhibit the growth of OSCC,and the combined drug is more effective.Natural medicinal plants are promising candidates for the treatment of OSCC.

natural medicinal plantactive ingredientsoral squamous cell carcinomamechanismsignaling pathwayreview

REN Qun-li、LI Xiao-lan、TIAN Tian、LI Shuang、SHI Rong-yi、WANG Qian、ZHU Yuan、WANG Miao、HU Huan、LIU Jian-guo

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School of Stomatology,Zunyi Medical University,Zunyi,Guizhou Province(563000),China

Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution,Zunyi Medical University,Zunyi,Guizhou Province(563000),China

School of Basic Medicine,Zunyi Medical University,Zunyi,Guizhou Province(563000),China

National and Provincial First-Class Undergraduate Major Construction Point for 2020-Stomatology Major of Guizhou ProvinceZunyi Innovative Talent Team of Oral Diseases Immunity and Medical Biomaterials ResearchScience and Technology Project of ZunyiSpecial Project of Zunyi Medical University for Academic New TalentsTraining Program Project of Zunyi Medical University for 2022 National and Provincial College Students Innovation and EntrepTraining Program Project of Zunyi Medical University for Tutor Tendering Type College Students Innovation and Entrepreneursh

QJH202128ZSRC20221ZSKH-HZ202060QKHPT20185772-067S202210661227ZYDC2022042

2024

10.1007/s11655-024-3804-7

中国结合医学杂志(英文版)
中国中西医结合学会 中国中医研究院

中国结合医学杂志(英文版)

CSTPCD
影响因子：1.056
ISSN：1672-0415
年,卷(期)：2024.30(9)