Advance on Chinese Medicine for Hypertensive Renal Damage:Focus on the Complex Molecular Mechanisms

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外文摘要：Hypertensive renal damage(HRD)is a major cause of end-stage renal disease.Among the causes of end-stage renal disease,HRD accounts for nearly 34％of the total number of cases.Antihypertensive treatment is primarily drug-based,but therapeutic efficacy is less effective and can have serious side effects.Chinese medicine(CM)has significant advantages in the treatment of HRD.CM is rich in various active ingredients and has the property of targeting multiple targets and channels.Therefore,the regulatory network of CM on disease is complex.A large number of CM have been employed to treat HRD,either as single applications or as part of compound formulations.The key possible mechanisms of CM for HRD include regulation of the renin-angiotensin-aldosterone system,antioxidation,anti-inflammation,rescue of endothelial function,regulation of vasoactive substance secretion and obesity-related factors,etc.This review summarized and discussed the recent advance in the basic research mechanisms of CM interventions for HRD and pointed out the challenges and future prospects.

外文关键词：

Chinese medicinehypertensive renal damagemolecular mechanismsresearch progress

作者：

LU Yan、XIE Xue-na、XIN Qi-qi、YUAN Rong、MIAO Yu、CONG Wei-hong、CHEN Ke-ji

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作者单位：

Laboratory of Cardiovascular Diseases,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China

School of Pharmacy,Macau University of Science and Technology,Taipa,Macau 999078,China

National Clinical Research Center for Chinese Medicine Cardiology,Beijing 100091,China

基金：

CACMS Innovation FundIrma and Paul Milstein Program for Senior Health of Milstein Medical Asian American Partnership FoundationChina Medical Association of Minorities Scientific Research ProjectChina Medical Association of Minorities Scientific Research Project

项目编号：

CI2021A009142022Z2069-6002012022Z2068-600401

出版年：

2024

DOI：

10.1007/s11655-024-3662-3

中国结合医学杂志(英文版)

中国中西医结合学会中国中医研究院

中国结合医学杂志(英文版)

CSTPCD

影响因子：1.056

ISSN：1672-0415

年,卷(期)：2024.30(10)