An observation on clinical efficacy of Xuebijing combined with Qingyi decoction for treatment of patients with severe acute pancreatitis
Objective To observe the clinical effect of Xuebijing injection combined with Qingyi decoction for treatment of patients with severe acute pancreatitis(SAP). Methods A total of 80 patients of SAP in our hospital were randomly divided into treatment group and control group(each,40 cases). Conventional treatment was given to the two groups,the treatment group additionally was treated by Xuebijing 100 ml intravenous injection,twice a day, and at the same time,Qingyi decoction(radix bupleuri,scutellaria root,white peony,corydalis tuber,rhubarb, mirabilite,etc.)jejunum enema(one dose per day,daily 200 ml juice divided into 4 times to be administered into the jejunal tube)was applied. The changes of the rat of complication,the rate of transfer to perform operation,mortality, duration of abdominal pain,time for hospitalization,blood amylase(AMS)recovery time and acute physiology and chronic health evaluation system Ⅱ(APACHEⅡ)score were observed in the two groups. Results In treatment group,the complication rate(10.0%),transfer operation rate(5.0%)and mortality(2.5%)were significantly lower than those of the control group(47.5%,32.5% and 20.0%,all P<0.05). The duration of abdominal pain(day:8.4±2.9),the hospitalization time(day:24.2±6.8)and blood AMS recovery time(day:21.8±7.1)in treatment group were significantly shorter than those of the control group(13.3±5.8,25.1±7.2,6.9±6.7,all P<0.05). APACHEⅡ had no statical difference compared with two groups after treatment(7.95±5.40 vs. 5.13±1.95,P>0.05) Conclusion Xuebijing injection combined with Qingyi decoction for treatment of SAP can reduce the rate of complication,the number of cases necessary to be operated,shorten the hospitalization time and decrease the mortality.
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NSTL
万方数据
维普
