Effect of Jiawei Chengqi decoction combined with enteral nutrition emulsion on intensive care unit stroke patients by regulating brain-derived neurotrophic factor/tyrosine kinase receptor B signaling pathway
Objective To study the mechanism of Jiawei Chengqi decoction combined with enteral nutrition emulsion in the treatment of stroke patients by regulating brain-derived neurotrophic factor/tropomyosin kinase receptor B(BDNF/TrkB)signaling pathway.Methods A total of 200 stroke patients treated in the intensive care unit(ICU)of Xingtai Third Hospital from January 2020 to October 2022 were selected as the study objects,and the patients were randomly divided into observation group and control group,with 100 cases in each group.The control group was treated with enteral nutrition emulsion,and the observation group was treated with Jiawei Chengqi decoction on this basis[drug composition:Raw Rhubarb 10 g(bottom),Raw Malt 30 g,Sodium Powder 6 g(flush),Substitute Ochre 30 g(first),Magnolia Officinalis 10 g,Stir-fried Raphanus Japonicus 15 g,Stir-fried Fructus Aurifolius 15 g,Spiral Flower 10 g(pan-fried),whole Trichosanthes 30 g.100-200 mL of juice in water was consumed in 2 separate doses,once daily].The clinical efficacy,nutritional indexes[total protein(TP),hemoglobin(Hb),prealbumin(PA),albumin(ALB)],intestinal mucosal barrier indexes[diamine oxidase(DAO),procalcitonin(PCT),D-lactic acid],traditional Chinese medicine(TCM)syndrome score,TrkB,BDNF,and calcitonin gene-related peptide(CGRP)level differences were compared between the two groups after treatment.Results The total clinical effective rate of the observation group was significantly higher than that of the control group[92.00%(92/100)vs.81.00%(81/100),P<0.05].The levels of nutritional indexes TP,Hb,ALB,intestinal mucosal barrier,TCM syndrome score,TrkB,BDNF and CGRP in the two groups after treatment were significantly lower than those before treatment,and the nutritional indexes TP,Hb and PA in the observation group were significantly higher than those in the control group after treatment[TP(g/L):68.09±10.28 vs.64.53±9.81,Hb(g/L):133.48±33.38 vs.121.38±30.72,PA(mg/L):231.29±22.75 vs.219.73±20.48,all P<0.05],the levels of nutrition index ALB,mucosal barrier index,TCM syndrome score,TrkB,BDNF and CGRP were significantly lower than those of control group[ALB(g/L):36.78±5.32 vs.39.49±5.48,DAO(kU/L):3.19±0.53 vs.3.91±0.59,PCT(μg/L):5.05±0.68 vs.6.14±0.89,D-lactic acid(mmol/L):0.14±0.03 vs.0.22±0.03,abdominal pain and diarrhea scores:1.34±0.62 vs.2.45±0.73,abdominal cold pain scores:1.63±0.63 vs.2.38±1.03,waist and knee tenderness scores 0.96±0.41 vs.1.75±0.52,diet scores:1.14±0.41 vs.1.58±0.69,cold body cold integral scores:0.97±0.42 vs.1.68±0.54,TrkB(ng/L):285.02±28.15 vs.375.84±36.12,BDNF(ng/L):1 306.84±244.83 vs.1 718.84±378.83,CGRP(ng/L):79.68±9.56 vs.87.27±11.01,all P<0.05].Conclusion Using Jiawei Chengqi decoction in conjunction with enteral nutrition emulsion for treating stroke patients in the ICU can significantly improve the intestinal mucosal indexes and nutritional indexes of patients,making it a promoting approach in clinical practice.
NETL
NSTL
万方数据
