Acute clinical characteristics and follow-up outcome of 9 pediatric patients with diquat poisoning
Objective To summarize the long-term effect of diquat on organ function in poisoned children,so as to provide experience in diagnosis and treatment for clinicians.Methods A retrospective study method was adopted.The clinical data of 9 children with diquat poisoning treated in the department of pediatric intensive care unit(PICU)of Shengjing Hospital Affiliated to China Medical University from November 2018 to December 2021 were selected,and they were followed up for one year after discharge,in order to judge the long-term effects of diquat on the poisoned children.Results Among the 9 cases,3 cases were taken by mistake with low dose,6 cases were taken orally by themselves.After poisoning,7 cases had different degrees of gastrointestinal symptoms,such as nausea,vomiting,abdominal pain;3 cases had respiratory symptoms,including shortness of breath,chest tightness,chest pain;1 case had urinary symptom,oliguria;1 case had neurdogical symptom,lethargy.Organ injury:acute renal injury in 3 cases,lung injury in 3 cases,liver injury in 1 case,myocardial injury in 1 case,rhabdomyolysis in 1 case.After admission,the children were given symptomatic treatment such as gastric lavage,adsorption,catharsis and antioxidation,5 cases were given hemoperfusion,1 case was given plasma exchange,and 2 cases were given continuous renal replacement therapy(CRRT).The hospitalization time was 3-16 days.All the children were discharged after improvement,and no organ function damage was found in the follow-up.Conclusions Diquat poisoning can cause organ damage including lung,liver and kidney function and striated muscle.However after active treatment,the prognosis is relatively good,and no long-term sequelae.It is crucial to prevent poison absorption and facilitate poison excretion immediately after poisoning.Implementing antioxidation and blood purification therapy can help minimize organ function damage and enhance prognosis.
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