Objective In order to study the target genes and mechanism of effective components of Angelica dahurica by bioinformatics analysis.Methods The target genes of effective active components of Angelica dahurica were analyzed through traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP).The target genes of melanin related diseases were obtained from the comprehensive database GeneCards,the genes related to melanin deposition disease were screened from the chip GSE1 14445,and the genes related to melanin disease in the target genes of effective active components of Angelica dahurica were obtained after intersection.Screening autophagy related genes from autophagy database,the genes related to melanin disease and autophagy in the target genes of effective active ingredients of Angelica dahurica were obtained by intersection of the genes related to melanin disease and autophagy in the target genes of effective active ingredients of Angelica dahurica.The gene enrichment pathways related to melanin disease and autophagy in the target genes of effective active components of Angelica dahurica were analyzed online by Metascape.Results Totally 5 342 drug target genes of Angelica dahurica were obtained,including 152 genes related to melanin disease,and nine genes related to melanin disease and autophagy.The genes related to melanin disease and autophagy in the target genes of effective active components of Angelica dahurica were mainly enriched in phosphoinositide 3-kinase protein kinase B(P13K-Akt),mitogen-activated protein kinase(MAPK)and rat sarcoma viral oncogene homolog(RAS)pathways.Conclusion A total of nine Angelica dahurica drug target genes related to melanin disease and autophagy were screened.These nine genes were mainly enriched in PI3K-Akt,MAPK and RAS pathways.The results of this study preliminarily revealed the material basis of the efficacy of Angelica dahurica,which can provide references for clarifying the mechanism of Angelica dahurica promoting melanin degradation.
维普
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