Objective In order to investigate the efficacity and safety of Haoqin Huaban optimized decoction by using multicenter,double-blinded,and placebo randomized controlled method.Methods According to the criteria of diagnosis,inclusion,and exclusion,126 patients with polymorphic light eruption(PLE),from Beijing Hospital of traditional Chinese medicine(TCM),Beijing Shunyi Hospital of TCM,Beijing Huimin Hospital were filtered out.The patients were randomly divided into trcatment group and control group.Eighty-four patients in the treatment group were treated with granular Haoqin Huaban optimized decoction.Forty-two patients in the control group received oral placebo.The observation would be taken once a week,four times constantly with an assessment of therapeutic efficacy.The assessment was divided into four parts:first,the eczema area and severity index(EASI)scale which include erythema,papules,epidermal exfoliation,exudation/c rusting,lichen and affected area.Second,the scores of TCM main clinical syndromes which consist of pruritus,upset,thirst,yellow urine,dry stool.Third,life quality is composed of dermatology life quality index(DLQI)scale and health questionnaire(SF-36)scale.Last,patient safety indicators prior and after the therapeutic need to be monitored.Results After four weeks of treatment,the healing rate(76.92％)and total effective rate(94.87％)in the treatment group were significantly higher than those in the control group(P＜0.001).Compared with the control group,EASI score decreased significantly in the treatment group(P＜0.001),and erythema,papules and affected area improved significantly in the treatment group(P＜0.05).The total score of TCM syndrome in the treatment group decreased significantly compared with the control group(P＜0.05).After four weeks of treatment,the scores of physiological function,physiological function,physical pain,social function and role function in the treatment group were higher than those in the control group(P＜0.05),and the DLQI score was significantly lower than that in the control group(P＜0.05).There were no abnormal values among safety indicators and no adverse events happened.Conclusion Haoqin Huaban optimized decoction can effectively improve the clinical symptoms and signs of patients with PLE without obvious adverse reactions.
维普
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