Expression of Peripheral Blood CXCL10 and Its Receptor CXCR3 in Patients with Recurrent Genital Herpes Virus Type 2 Infection and Its Relationship with Prognosis
Expression of Peripheral Blood CXCL10 and Its Receptor CXCR3 in Patients with Recurrent Genital Herpes Virus Type 2 Infection and Its Relationship with Prognosis
Objective In order to explore the expression of peripheral blood CXC chemokine ligand 10(CXCL10)and CXC chemokine receptor 3(CXCR3)in patients with recurrent genital herpes virus type 2 infection and its relationship with prognosis.Methods Totally 102 patients with recurrent genital herpes virus type 2 infection who were admitted to the hospital from July 2019 to July 2020 were selected,and 94 healthy people who came to the hospital for physical examination during the same period were selected.The levels of CXCL10 and CXCR3 in peripheral blood of patients with recurrent genital herpes virus type 2 infection and healthy subjects were compared.According to clinical stage,102 patients with recurrent genital herpes virus type 2 infection were divided into breakout stage(44 cases)and stable stage(58 cases),the levels of CXCL10 and CXCR3 in peripheral blood of patients in the breakout and stable stages were compared.The patients were followed up for one year,and the recurrence rate of the patients was counted,univariate analysis was used to analyze the factors affecting the frequent recurrence of patients with recurrent genital herpes virus type 2 infection,and logistic regression analysis was performed on the factors,receiver operating curve(ROC)was used to analyze the value of peripheral blood CXCL10 and CXCR3 levels in predicting frequent relapse in patients with recurrent genital herpes virus type 2 infection.Results The level of CXCL10,CXCR3 in peripheral blood of patients with recurrent genital herpes virus type 2 infection were lower than that of healthy subjects(P＜0.05).The levels of CXCL10,CXCR3 in peripheral blood of patients in breakout stage were lower than those in patients in stable stage(P＜0.05).During one year follow-up,28 cases of the 102 patients with recurrent genital herpes virus type 2 infection had frequent recurrence,the composition ratio of the number of sexual partners of three or more in patients with frequent recurrence was higher than those in patients with infrequent recurrence(P＜0.05).The levels of peripheral blood interferon-γ(IFN-γ),CXCL10 and CXCR3 in patients with frequent recurrence were lower than those in patients with infrequent recurrence(P＜0.05).Logistic multivariate regression analysis showed that the number of sexual partners,CXCR3 and CXCL10 were independent risk factors for frequent recurrence in patients with recurrent genital herpes virus type 2 infection(P＜0.05).The ROC analysis showed that the optimal cut-off points of CXCL10 and CXCR3 in peripheral blood for predicting frequent recurrence in patients with recurrent genital herpes virus type 2 infection were 10.14 pg/mL and 8.20 ng/mL;and the areas under the curve(AUC)were 0.806 and 0.822,the combined specificity and AUC of the two were 91.89％and 0.914,respectively.Conclusion The levels of CXCL10 and CXCR3 in patients with recurrent genital herpes virus type 2 infection are abnormally reduced,both of which are closely related to frequent recurrence of patients,and they can be used as sensitive indicators for clinical prediction of frequent recurrence of patients with recurrent genital herpes virus type 2 infection.
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