Objective In order to observe the effects of Xinyinling granule on T helper cell 22(Th22)and its cytokines in peripheral blood of patients with blood heat syndrome of psoriasis vulgaris(PsV).Methods Thirty patients with blood heat syndrome of PsV treated in the dermatology department of Tianjin academy of traditional Chinese medicine affiliated hospital from December 2019 to December 2020 were selected as the study group,and 10 healthy volunteers were taken as the control group.The study group was treated with Xinyinling granules for eight weeks.Before and after treatment,the proportion of Th22 cells in peripheral blood was detected by flow cytometry,interleukin-22(IL-22)level was detected by enzyme-linked immunosorbent assay(ELISA),and IL-22 mRNA expression level was determined by real-time fluorescence quantitative polymerse chain reaction(RT-qPCR).Results After treating with Xinyinling granule,psoriasis area and severity index(PASI),Chinese medicine symptom complex score,and dermatology life quality index(DLQI)in the study group were significantly lower than before treatment(all P<0.05).The proportion of Th22 cells,the expression levels of IL-22 and IL-22 mRNA in peripheral blood of the study group were significantly decreased after treatment(P<0.01).Conclusion Xinyinling granules may treat PsV by inhibiting the activation of Th22 cells and down-regulating the expression of its cytokines.
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