Correlation between Sirt3 and DAB2IP Expression and Pathological Features in Cutaneous Squamous Cell Carcinoma and Their Significance in Predicting Postoperative Recurrence
Objective In order to analyze the relationship between tissue silencing information regulator 3(Sirt3)and DOC2/DAB2 interaction protein(DAB2IP)expression and pathological features in cutaneous squamous cell carcinoma(cSCC),and to analyze the predictive value of both for postoperative recurrence.Methods A total of 193 patients with cSCC in our hospital from July 2018 to June 2020 were selected,who underwent extended excisional lesion surgery.The expression of Sirt3 and DAB2IP in tumor tissues and paraneoplastic tissues of cSCC patients was compared,the postoperative recurrence was counted and the relevant information of postoperative recurrence and non-recurrence cSCC patients was compared.The influence factors of postoperative recurrence in cSCC patients were analyzed by logistic regression,and the Sirt3 and DAB2IP prediction of cSCC patients was analyzed by receiver operator characteristic(ROC)curve.The value of postoperative recurrence,the decision curve of Sirt3 and DAB2IP predicting postoperative recurrence in cSCC patients,and postoperative recurrence in cSCC patients with different Sirt3 and DAB2IP expression were analyzed.Results The number of cSCC patients with high expression of Sirt3 and DAB2IP in tumor tissue was higher than that with low expression(P<0.05);42 patients recurred after surgery and 151 patients were cured completely.The diameter of lesions,degree of differentiation,positive postoperative margins,and expression of Sirt3 and DAB2IP in cSCC patients with recurrence after surgery were significantly different from those without recurrence(P<0.05).The degree of differentiation was hypodifferentiation,postoperative cut-off positive Sirt3 and high expression of DAB2IP were independent risk factors for postoperative recurrence in cSCC patients(P<0.05).The area under the curve(AUC)value of the combined Sirt3 and DAB2IP test for predicting postoperative recurrence in cSCC patients was 0.669,which was higher than the two tests alone;decision curve analysis showed that when the risk threshold was 0.20 to 0.45,the net benefit rate of combined Sirt3 and DAB2IP testing was greater than that of testing alone;the postoperative recurrence rate was significantly higher in cSCC patients with Sirt3+/DAB2IP+than in Sirt3+/DAB2IP-,Sirt3-/DAB2IP+,and Sirt3-/DAB2IP-patients(P<0.05).Conclusion The high expression of both Sirt3 and DAB2IP in cSCC tissues indicates that patients are at high risk of postoperative recurrence,and their expression can be detected to provide a basis for early clinical screening.
Cutaneous squamous cell carcinomaSilent information regulator 3DOC2/DAB2 interacting proteinRecurrence
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