Objective In order to observe the clinical efficacy and changes in related inflammatory factors of the treatment of psoriasis vulgaris(PsV)with blood heat syndrome using Siteng mixture and self-made Qingre Xiaoyin medicinal bath formula alone and in combination.Methods Totally 120 patients with blood heat syndrome PsV who met the inclusion criteria were enrolled in our hospital and randomly divided into medicine bath group,traditional Chinese medicine(TCM)group,and combination group,with 40 patients in each group.The treatment lasted for four weeks.Psoriasis area and severity index(PASI)scores were recorded and the changes of serum interleukin-17(IL-17),IL-22,tumor necrosis factor-α(TNF-α)and vascular endothelial growth factor(VEGF)were detected by enzyme linked immunosorbent assay(ELISA)at week 0 and 4,respectively.Results After four weeks of treatment,the effective rate of the medicine bath group(38 cases)was 31.58%,the TCM group(36 cases)was 41.67%,and the combined group(38 cases)was 68.42%.After treatment,the PASI score of the three groups decreased significantly than before treatment(P<0.01).The decreasing in PASI score in the combination group(6.16±2.25)was significantly greater than that in the medicine bath group(3.13±1.61)and the TCM group(5.47±2.26,P<0.01).After treatment,the serum concentrations of IL-17,IL-22,TNF-α and VEGF in the three groups were significantly lower than those before treatment(P<0.01).The serum concentrations of VEGF were significantly lower than those before treatment(P<0.01).In combination group,serum concentration levels of IL-17(40.74±12.70),IL-22(35.17±2.93),TNF-α(22.22±1.72)and VEGF(266.00±11.45)were significantly lower than those of IL-17(57.02±12.57),IL-22(54.55±0.56),and TNF-α(28.05±2.56)and VEGF(287.60±11.33)in the medicated bath group,also lower than those of IL-17(57.61±15.04),IL-22(54.45±0.63),and TNF-α(27.43±2.15)and VEGF(285.10±10.33)in the traditional Chinese medicine group(P<0.01).All three groups had patients who withdrew due to safety reasons,including two cases in the medicine bath group,four cases in the TCM group,and two cases in the combination group.Conclusion Both Siteng mixture and self-made Qingre Xiaoyin medicinal bath formula have certain therapeutic effects on PsV with blood heat syndrome.The combination of the two can significantly improve the treatment effectiveness.Moreover,the combination of the two has significant inhibitory effects on inflammatory factors in patients with PsV of blood heat syndrome compared to single use.The combination of self-made Qingre Xiaoyin medicinal bath formula and Siteng mixture in the treatment of PsVwith blood heat syndrome is worthy of clinical use and promotion.
NETL
NSTL
万方数据
