Objective In order to investigate the influence of itch and sleep quality on the quality of life of adults with moderate-to-severe atopic dermatitis(AD),with the goal of enhancing current disease management and treatment strategies.Methods A total of 244 adults with severe AD treated at the AD clinic of the Skin Disease Hospital in Shanghai from January 2023 to December 2023 were conveniently sampled for a cross-sectional study.General information questionnaire,dermatology life quality index(DLQI),AD control tool(ADCT),itch numerical rating scale(NRS),and sleep visual analog scale(VAS)questionnaires were utilized.Multifactorial logistic regression analysis was employed to investigate factors influencing the impaired quality of life in adults with severe AD.Restricted cubic spline analysis was conducted to further explore the relationship between itch severity,sleep quality,and impaired quality of life in adults with severe AD.Results A total of 244 adults with severe AD were included in the study,with 117 males and 127 females,of which 192 patients experienced impaired quality of life(DLQI score>5).Compared to the group with unimpaired quality of life,patients in the impaired quality of life group had significantly higher ADCT scores(P<0.001),itch NRS scores(P<0.001),and sleep VAS scores(P=0.001).Logistic regression analysis results indicated that itch severity and sleep quality were independent risk factors for impaired quality of life in adults with severe AD.Additionally,there was a significant linear relationship among itch severity,sleep quality scores,and impaired quality of life in adults with severe AD.Conclusion Itchiness and sleep quality are important fators affecting the quality of life of adults with moderate-to-severe AD.Paying attention to itchiness and sleep quality not only helps to improve the overall quality of life of AD patients but also contributes to the long-term management of AD patients.
Moderate-to-severe atopic dermatitisAdultsQuality of lifeItchSleep quality
NETL
NSTL
万方数据
