Clinical study on the treatment of postoperative anal pain of mixed hemorrhoids with Qi stagnation and blood stasis by Zhitong Rushen decoction modified combined with the enema of Kangfuxin liquid
Clinical study on the treatment of postoperative anal pain of mixed hemorrhoids with Qi stagnation and blood stasis by Zhitong Rushen decoction modified combined with the enema of Kangfuxin liquid
Objective To observe the clinical effect of Zhitong Rushen decoction modified combined with the enema of Kangfuxin liquid in the treatment of postoperative anal pain of mixed hemorrhoids with Qi stagnation and blood stasis.Methods 100 patients with mixed hemorrhoids admitted in our hospital from January 2021 to December 2022 were selected and divided into three groups——Group A,Group B and Group C,according to the randomized numerical table method.30 cases in Group A were treated with conventional western medicine;35 cases in Group B were treated with the enema of Kangfuxin liquid on the basis of Group A;35 cases in Group C were treated with Zhitong Rushen decoction modified on the basis of Group B.On the 1st and 7th day after surgery,wound edema and granulation tissue growth were evaluated,and anal pain was evaluated by the Digital Pain Scale(NRS),and the time of anal edema resolution,wound secretion disappearance and wound healing in the three groups were recorded.The levels of tumor necrosis factor-α(TNF-α),epidermal growth factor(EGF),β-endorphin(β-EP),interleukin-22(IL-22),fibronectin(FN)and NRS cular endothelial growth factor(VEGF)in three groups were detected.The proctoanal inhibitory reflex threshold,anal resting pressure and anal high pressure band length were measured before and one month after operation.Results Group C had lower trabecular edema and NRS scores and higher trabecular granulation tissue growth scores than Groups A and B(P＜0.05).The time of wound secretion disappearing,anal edema subsiding and wound healing in Group C were shorter than those in Groups A and B(P＜0.05).The inhibitory reflex threshold and resting pressure of proctoanal canal in Group C were higher than those in Groups A and B(P＜0.05),and the length of high pressure band of proctoanal canal in Group C was shorter than those in Groups A and B(P＜0.05).The levels of TNF-α and IL-22 in Group C were lower than those in Groups A and B(P＜0.05),and the levels of β-EP,EGF,FN and VEGF were higher than those in Groups A and B(P＜0.05).Conclusion Zhitong Rushen decoction modified combined with the enema of Kangfuxin liquid can inhibit the level of inflammatory factors,regulate pain mediators and EGF,FN,VEGF indicators,alleviate anal pain,promote wound healing and improve anal function.
关键词
止痛如神汤加减方/康复新液灌肠/炎症因子/疼痛介质
Key words
Zhitong Rushen decoction modified/enema of Kangfuxin liquid/inflammatory factors/pain mediators
维普
万方数据