Effect of Huayu Tongbi formula combined with manual massage in the treatment of medium-term knee osteoarthritis and preliminary analysis of its related mechanism
Effect of Huayu Tongbi formula combined with manual massage in the treatment of medium-term knee osteoarthritis and preliminary analysis of its related mechanism
Objective To observe the clinical effect of Huayu Tongbi formula combined with manual massage in the treatment of mid stage knee osteoarthritis(KOA),and analyze its therapeutic mechanism preliminarily.Methods 102 KOA patients admitted to our hospital from December 2021 to June 2023 were randomly divided into an observation group(51 cases)and a control group(51 cases)based on the order of their visits.The control group were given Glucosamine sulfate capsules,Diclofenac sodium sustained-release tablets and the traditional Chinese medicine Huayu Tongbi prescription orally.On this basis,the observation group received manual massage treatment,and both groups were treated for 4 weeks.The scores of Osteoarthritis index(WOMAC)and Lequesne index of Xi'an University and McMaster University before and after treatment were compared between the two groups,and the knee joint space,knee joint space angle,serum transforming growth factor-β1(TGF-131)and Smad1 protein level were compared between the two groups,and the total effective rate of treatment of the two groups was compared.Results After treatment,the scores of WOMAC stiffness,pain,joint function,and Lequesne scores of the observation group were lower than those of the control group(P＜0.05);The medial and lateral gaps of the knee joint were larger than those of the control group(P＜0.05),and the knee joint gap angle was smaller than that of the control group(P＜0.05);The level of Serum TGF-β1 was lower than that of the control group(P＜0.05),and the level of Smad1 was higher than that of the control group(P＜0.05);The total effective rate of treatment was higher than that of the control group(P＜0.05).Conclusion The combination of Huayu Tongbi Formula and manual massage can expand and balance joint space,improve joint function,and it has a significant effect on mid-term KOA.Its mechanism of action may be related to the regulation of TGF-β1,Smad1 protein expression.
维普
万方数据