Objective To analyze the clinical effect of Liujunzi decoction combined with enteral nutrition on gastrointestinal dysfunction patients with mechanical ventilation.Methods A total of 80 ICU patients with mechanical ventilation gastrointestinal dysfunction treated in hospital from November 2020 to November 2022 were selected,and grouped into random number tables.40 cases of enteral nutrition group were treated with enteral nutrition at the same time as basic symptomatic treatment;40 cases of Liujunzi decoction combined group were treated with Liujunzi decoction at the same time as enteral nutrition group.The clinical efficacy of the two groups was compared.Gastrointestinal dysfunction,acute physiological and chronic health score Ⅱ(APACHEⅡ),and nutritional risk screening evaluation Form(NRS 2002)were evaluated before and after treatment.Mechanical ventilation time and ICU stay time of patients in the two groups were recorded,and antrum contraction amplitude,gastric half-emptying time and antrum contraction frequency were examined.Soluble myelocyte trigger receptor 1(sTREM-1),gastrin-17(G-17),growth hormone releasing peptide(Ghrelin),percentage of neutrophils,CD4+,CD8+,albumin,transferrin levels of T lymphocyte subsets were measured,and the incidence of abdominal distension,diarrhea,gastric retention,and infection in the two groups were recorded during treatment.Results The total effective rate of Liujunzi decoction combined group was 97.50％,which was significantly higher than that of enteral nutrition group(80.00％)(P＜0.05).The scores of APACHE Ⅱ,gastrointestinal dysfunction and NRS 2002 in Liujunzi decoction combined group were lower than those in enteral nutrition group(P＜0.05),and the mechanical ventilation time,ICU stay time and stomach half-empty time in Liujunzi decoction combined group were shorter than those in enteral nutrition group(P＜0.05).The magnitude and frequency of antrum contraction in Liujunzi decoction combined group were higher than those in enteral nutrition group(P＜0.05).The levels of G-17,Ghrelin,CD4+,albumin and transferrin in Liujunzi decoction combined group were higher than those in enteral nutrition group(P＜0.05).The levels of sTREM-1,neutrophil percentage and CD8+in Liujunzi decoction combined group were lower than those in enteral nutrition group(P＜0.05).The complication rate of Liujunzi decoction combined group was 5.00％,which was significantly lower than that of enteral nutrition group(27.50％)(P＜0.05).Conclusion Liujunzi decoction combined with enteral nutrition in the treatment of patients with mechanical ventilation gastrointestinal dysfunction can inhibit inflammation,improve immune function and nutritional status,enhance gastric motility,improve condition,enhance clinical efficacy and reduce complications.
关键词
六君子汤/肠内营养/重症监护室/机械通气/胃肠功能障碍/炎症/免疫功能
Key words
Liujunzi decoction/enteral nutrition/ICU/mechanical ventilation/gastrointestinal dysfunction/inflammation/immune function
维普
万方数据