Objective To analyze the biocompatibility and in vivo bone regeneration ability of biodegradable Zn-2Ag-0.04Mg alloy through animal experiments.Methods Thirty experimental rabbits were randomly divided into three groups:Zn stent group,Zn-2Ag stent group,and Zn-2Ag-0.04Mg stent group(10 rabbits in each group).After establishing a rabbit femoral defect model,different materials of stents were used for fixation.Six weeks and six months after surgery were selected as observation points.Part of the femur of the white rabbits was taken out at the above time points,and Micro CT was used to scan and reconstruct the area with a diameter of 3 mm around the distal femoral entrance,Analyze the osteogenic performance of the stent in vivo,observe the healing of local bone defects using X-ray,and observe the histological condition of the femur.Results No abnormal behavior or death was observed in the enrolled experimental rabbits,and the wounds healed well without infection or exudation;The two-dimensional and three-dimensional micro CT results showed that the newly formed bone in the Zn-2Ag-0.04Mg scaffold group was significantly more than that in the Zn scaffold group,and the bone volume in the Zn-2Ag-0.04Mg alloy scaffold group was larger(P＜0.05).The osteogenic index of the Zn-2Ag-0.04Mg scaffold group was also higher than that of the Zn scaffold group(P＜0.05).At 6 months,the Zn-2Ag-0.04Mg scaffold was smaller than that of the Zn group or Zn-2Ag group(P＜0.05).The HE staining of the liver,kidneys,and heart did not detect any abnormalities,confirming the biological safety of the Zn-2Ag-0.04Mg alloy stent.Conclusion The Zn-2Ag-0.04Mg scaffold has good biocompatibility and in vivo bone regeneration ability,and has good clinical application prospects.
维普
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