Angiogenesis Study of XFZYD on Limb Ischemic Model of Rat
Objective:To discuss the therapeutic angiogenic effects of Xuefu Zhuyu Decoction (XFZYD) on limb ischemic model of rat.Methods SD Rat ischemic limb model was established by embolization with Bletilla microsphere suspension,and got low amputation on the third day after injection of Bletilla microsphere,then took granulation tissues respectively on the 36th,48th and 72th hour after amputation.Observe ischemia repair situation and count numbers of blood vessels by routine pathological section.Results The ischemic limb of model rat was characterized by cyanosis,limp or drag after the first day of embolization.36 hours after amputation,vessel number of high and regular dose of XFZYD group were both obviously higher than that of saline group,especially the high dose group ; 48 hours after amputation,the regular dose group could not improve the vessel growth,but the vessel number of high dose group still significantly higher than the saline group.Conclusion XFZYD could shortly promote vessel growth in granulation tissues to improve repairment of ischemic tissue.
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维普
