溃疡性结肠炎的肠道免疫研究进展
Research Progress on Intestinal Immunity in Ulcerative Colitis
李洋 1宋志前 2鲁欣悦 2王淳 2彭诗涛 2张婷 3宁张弛2
作者信息
- 1. 首都医科大学附属北京中医医院,北京 100010
- 2. 中国中医科学院中医基础理论研究所,北京 100700
- 3. 中国中医科学院广安门医院,北京 100053
- 折叠
摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种病因尚不十分明确的结肠和直肠慢性非特异性疾病.UC与肠道免疫关系密切,肠相关淋巴组织以及固有层含有丰富的免疫细胞,对于维持肠道免疫稳态具有重要作用.辅助性T细胞(T helper cell,Th)17/调节性T细胞(T regulatory cell,Treg)失衡与UC肠道免疫稳态息息相关,而Th17/Treg细胞的分化和功能受到细胞代谢重编程的影响.本文主要从与UC相关的肠相关淋巴组织以及固有层内多种免疫因素、Th17/Treg细胞代谢重编程以及中药免疫调节治疗UC现状 3 个方面进行综述,以期为UC相关研究提供参考.
Abstract
Ulcerative colitis(UC)is a chronic nonspecific disease of the colon and rectum whose etiology is not well defined.UC is closely related to intestinal immunity.Intestinal-associated lymphoid tissue and lamina propria contain abundant immune cells,which play an important role in maintaining intestinal immune homeostasis.The imbalance of T helper cell(Th)17/T regulatory cell(Treg)was proved to be relative to intestinal immune homeostasis of UC,which was affected by metabolic reprogramming of cells.To provide a reference for UC research,this paper mainly reviewed the studies from three aspects:enteric-associated lymphoid tissue and various immune factors in lamina propria related to UC,metabolic reprogramming of Th17/Treg cells,and traditional Chinese medicine immune regulation treatment of UC.
关键词
溃疡性结肠炎/肠道免疫/Th17细胞/Treg细胞/代谢重编程Key words
Ulcerative colitis/Intestinal immunity/T helper cell/T regulatory cells/Metabolic reprogramming引用本文复制引用
基金项目
中国中医科学院科技创新工程项目(CI2021A04201)
中国中医科学院优秀青年科技人才(创新类)项目(ZZ14-YQ-035)
中央级公益性科研院所基本科研业务费专项(YZ202141)
出版年
2024
国家科技期刊平台
NSTL
万方数据