Analysis of the Modern Biological Mechanism of"Dampness Evil Accumulation"in Chronic Kidney Disease Based on Lipid Nephrotoxicity Theory and Potential Targets of"Treating from Dampness"
Chronic kidney disease(CKD)is a clinical syndrome with abnormalities of renal structure or function caused by multiple factors.Generally,CKD has an occult onset and lingering course."Dampness"is not only the pathologic results but also pathogenic factors,and can mixed with wind,water,heat,blood stasis,turbidity,toxins,thus delaying progress.From the perspective of traditional Chinese Medicine(TCM),"Dampness evil accumulation"plays an essential role in the development of CKD,and clinical treatment of CKD from the perspective of"eliminating dampness"has also achieved good efficacy.Since the theory of"lipid nephrotoxicity"was proposed,more and more modern biological researches have revealed the mechanism and key role of lipid metabolism in CKD progression.By sorting and comparing the characteristics of"lipid metabolism"and"dampness",we think that"the disorder of lipid metabolism"can be regarded as an important microscopic manifestation of"dampness"in CKD.Reprogramming of lipid metabolism affects immunity,inflammation,and fluid metabolism,thus leading to"wind-dampness""water-dampness""damp-heat",etc."Lipid metabolism regulation"also serve as the potential targets of"treating from dampness"of CKD.Herein,we try to explore the modern scientific connotation of"dampness evil accumulation"in CKD based on the theory of"lipid nephrotoxicity",and analyzes the modern biological mechanism of"treating from dampness"of CKD from the perspective of regulating lipid metabolism,hoping to provide a theoretical basis and new ideas for the clinical treatment of CKD in TCM.Our research will provide a theoretical basis and new ideas for the clinical treatment of CKD in TCM,and try to take the advantages of TCM in disease prevention.
Chronic kidney diseaseLipid nephrotoxicityLipid metabolismDampness evilTreating from dampness
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