Objective The ground beetle is a very important medicine in traumatology department.The female ground beetle is more usually used in clinic.This article is to study the differences between male and female ground beetle in treating the rat model with syndrome of blood stasis by traumatism.Methods 50 male Wistar rats were divided into 5 groups.Except for the normal group,the rats in the remaining groups used the method of falling heavy objects to prepare the traumatic blood stasis syndrome model.According to the principle of therapeutic administration,rats in the female group,male group,and male and female group were given female ground beetle decoction(1 g crude drug/kg),male ground beetle decoction(1 g crude drug/kg),mixed decoction of male and female ground beetle decoction(1 g crude drug/kg),while the rats in the normal group and model group were given equal amounts of purified water(10 mL/kg).After 5 days of continuous intervention,the leg diameters of the bruising areas before and after modeling were compared in each group of rats,and the serum levels of nitricoxide(NO)、endothelin(ET)-1、thromboxane(TX)B2、6-keto-protaglandin(6-K-PG)F1α were detected by colorimetric method and radioimmunoassay.Results Compare with the normal group,the bruising leg diameter,serum level of ET-1 and TXB2 of the rats in the model group were all higher(P<0.05),while the serum level of NO and 6-K-PGF1α were decreased in the model group rats(P<0.05).After intervention,the bruising leg diameter rats in each treatment group was reduced,and the levels of serum NO,ET-1,TXB2,and 6-K-PGFlα were significantly adjusted back(P<0.05).Comparing the female group,the male group and the male and female group,there was no statistically significant difference in the levels of each index(P>0.05).Conclusion Both female and male ground beetle have good curative effects on traumatic blood stasis syndrome,and there is no significant difference in the curative effects between the two.
Ground beetleMale and femaleSyndrome of blood stasis by traumatismET-1TXB26-K-PGF1α
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