Effect of Shenghui Yizhi Decoction Combined with Donepezil Hydrochloride on Behavioral and Psychological Symptoms of Patients with Mild to Moderate Alzheimer's Disease
Objective To observe the clinical effect of Shenghui Yizhi decoction combined with donepezil hydrochloride on behavioral and psychological symptoms of dementia(BPSD)in patients with mild-to-moderate Alzheimer's disease.Methods 70 patients with mild to moderate AD were randomly divided into treatment group and control group,with 35 cases in each group.The control group patients were given donepezil hydrochloride,and the treatment group patients were treated with Shenghui Yizhi decoction in addition,and the course of treatment was 6 months.Alzheimer's disease assessment scale-cognitive subscale(ADAS-cog)and neuropsychiatric inventory(NPI)were used before and after treatment to evaluate the cognitive function and behavioral and psychological symptoms of dementia.The adverse drug reactions were observed during the treatment.Results After treatment,the ADAS-cog and NPI scores in the two groups decreased significantly compared with those before treatment(P<0.05).The improvements of the treatment group were significantly better than those of the control group(P<0.05).NPI scores in the fields of depression,anxiety and apathy after treatment were lower than those before treatment(P<0.05),and compared with the control group,the scores were significantly lower in the treatment group(P<0.05).In addition,NPI scores of delusion,irritability,and sleep and night time behavior disorders in the treatment group after treatment were lower than those before treatment(P<0.05),and the improvements were better than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion BPSDs of patients with mild to moderate AD are mainly characterized by depression,apathy,irritability,anxiety,sleep and night time behavior disorders,and delusion.Shenghui Yizhi decoction combined with donepezil hydrochloride can improve cognitive function and relieve the above BPSD symptoms,and reduce score of TCM syndrome.The effect of integrated traditional Chinese and western medicine is better than that of donepezil hydrochloride alone,which is worthy of clinical promotion.
Alzheimer's diseaseShenghui Yizhi decoctionBehavioral and psychological symptomsCoordinating heart and kidneyMental illness
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