葛根素是近年来中医药领域的主要研究热点之一.本研究利用文献计量学方法,梳理了PubMed和Web of science数据库近年发表的与葛根素相关的文献,通过关键词及热点突现分析,结合图谱内容解读,得出以下结论:葛根素在重大慢性疾病,如心脑血管缺血性疾病、代谢性疾病、肿瘤等的临床前模型中展现出显著的疗效,其主要作用机制与抗炎、抗氧化、抗凋亡等相关,但不同作用机制间的相互关系尚不完全清楚;葛根素在糖尿病肾病、神经退行性疾病以及肠道菌群紊乱等疾病的治疗中展现出有较高的潜力,相关研究值得进一步探索;葛根素联合用药的协同作用愈发被关注,但其生物利用度低、高质量临床试验缺乏等问题日益凸显.总的来说,葛根素具有巨大的潜在应用价值,但相关作用机理及其关系仍需深入挖掘,相关的高质量临床研究亦值得关注和重视.
Exploratory Research on the Clinical Application of Puerarin in Major Chronic Diseases
Puerarin has become a prominent research focus in the field of traditional Chinese medicine in recent years.In this study,a bibliometric approach was employed to review literature related to puerarin published in the PubMed and Web of Science databases over the past five years.Through analysis of keywords and emerging trends,combined with interpretation of graphical representations,the following conclusions were drawn:Puerarin demonstrates significant therapeutic efficacy in preclinical disease models of major chronic diseases,such as cardiovascular and cerebrovascular ischemic diseases,metabolic disorders,and tumors.Its primary mechanisms of action are associated with anti-inflammatory,antioxidant,and anti-apoptotic effects,although whether there are interactions between these mechanisms remains uncertain.Puerarin shows promising potential in the treatment of diseases like diabetic nephropathy,neurodegenerative disorders,and disruptions in gut microbiota,warranting further exploration in related research.The synergistic effects of puerarin in combination with other medications are receiving increasing attention.However,challenges related to its low bioavailability and the lack of high-quality clinical trials are becoming more prominent.Overall,puerarin holds substantial potential for diverse applications,the underlying mechanisms and relationships require further in-depth exploration.Furthermore,relevant high-quality clinical studies also deserve attention and emphasis.