摘要
IgA肾病(IgA nephropathy,IgAN)是慢性肾脏病和终末期肾脏病的重要原因.本病的发病机制复杂,其中免疫机制一直是国内外研究的热点.近年来,中医学家从正邪失衡、营卫失和、脏腑功能失调、三焦功能紊乱、伏邪学说等方面探讨了本病免疫紊乱的病因病机,并通过临床和实验研究证实中医药可通过改善黏膜免疫、调节B细胞、调节T淋巴细胞、抑制补体系统异常激活等途径发挥调节IgA肾病免疫紊乱的作用.本文综述了中医药干预IgA肾病免疫机制的研究进展,并对其未来的研究方向进行展望,为中医药进一步临床实践及基础研究提供参考.
Abstract
IgA nephropathy(IgAN)is an important cause of chronic kidney disease and end-stage kidney disease.The pathogenesis of this disease is complex,and the immune mechanism has been a research hotspot at home and abroad.In recent years,traditional Chinese Medicine(TCM)practitioners have explored the etiology and pathogenesis of immune dysfunction in this disease from the aspects of the imbalance between healthy Qi and pathogenic factors,disharmony between nutrient and defensive Qi,dysfunction of the Zang-Fu organs,dysfunction of the triple energizer,and theory of latent pathogen.It has been confirmed that TCM may play a role in regulating IgAN immune disorders by improving mucosal immunity,regulating B cells,regulating T lymphocytes,and inhibiting abnormal activation of the complement system through clinical and experimental studies.This article reviews the research progress of TCM intervention in IgAN immune mechanism,and prospects its future research direction,which will provide reference for further clinical practice and basic research of TCM.
基金项目
国家自然基金面上项目(82074493)
河南省自然科学基金项目(232300421306)
河南中医药大学"双一流"创建工程中医学学科项目(HSRP-DFCTCM-2023-7-28)
河南省第二批中医药青苗人才培养项目(豫卫中医函[2021]16号)
中国民族医药学会科研项目(2021Z1194-400611)
国家科技期刊平台
NSTL
万方数据