首页|基于数据挖掘分析名中医治疗胃痛组方用药规律

基于数据挖掘分析名中医治疗胃痛组方用药规律

扫码查看
目的 应用数据挖掘技术,探究名老中医运用中医中药治疗以胃痛为主要表现的慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的用药规律,为临床提供诊疗依据.方法 借助古今医案云平台,搜索"名医病案库"中诊断胃痛且属萎缩性胃炎的案例,提取相关信息,进行标准化处理,对医案信息进行证候、中药频数、性味归经、功效、关联规则、聚类分析等分析.结果 共得到医案105 例,共计114 个中药复方,合计使用中药196 味,结果显示:胃阴不足证为最常见证候,中药四气以温、平药物为主,五味以甘、苦、辛为主,归经以归脾、胃、肝、肺经为主;频次>20 的中药共25 味,有白芍、甘草、白术等;通过关联规则分析,发现常用药对16 个,包括白芍-甘草、茯苓-白术、陈皮-半夏等;药证间关联规则结果显示,胃阴不足证常用白芍、石斛等,脾胃虚弱证常用白术、党参等,脾胃湿热证常用黄连、半夏等,脾虚湿阻证常用白术、陈皮,寒热错杂证常用黄连、黄芩等,肝胃气滞证常用白术、茯苓等,肝胃郁热证常用丹参、白芍等,胃络瘀血证则常用黄芪、丹参;通过聚类分析,将高频使用药物归为 6 大类.结论 通过数据挖掘,可发现该疾病临床证候复杂多样、虚实夹杂,名医用药治疗时涉及养阴缓急、健脾疏肝、清热燥湿等治法,涉及芍药甘草汤、四君子汤、半夏泻心汤等基础方,随症加减.
Prescription Rules of Stomachache of Famous Traditional Chinese Doctors Based on Data Mining
Objective We explored the famous TCM doctors'prescription regularity of the treatment for chronic atrophic gastritis with stomachache via data mining,to offer further support for clinical diagnosis and treatment.Methods With ancient and modern medical case cloud platforms,we searched for the case of atrophic gastritis with a stomachache in the"famous doctor's medical record library",built Excel to extract relevant information,standardized the collection of data,and applied data mining software for frequency statistics,association analysis,cluster analysis,and complex network analysis.Results With screening,we added up to 105 cases,114 Chinese herbal compounds,and 196 traditional Chinese medicines.The results showed that lack of stomach Yin syndrome was the most common syndrome,four properties were given priority to warm and flat,and five tastes were based on sweet,bitter,and pungent.The channel tropism of medicine was centered on the spleen,stomach,liver,and lungs.Traditional Chinese medicines which frequency>20 amount to 25,such as Radix Paeoniae Alba,Radix Glycyrrhizae,Atractylodes,Poria Cocos,Codonopsis,Salvia Miltiorrhiza,Dried Tangerine or Orange Peel,Astragalus Root,Spreading Hedyotis Herb,etc.Through the association rules analysis,a total of 16 traditional Chinese medicine pairs were used,such as Radix Paeoniae Alba-Radix Glycyrrhizae,Poria Cocos-Atractylodes,Dried Tangerine or Tangerine Peel,etc.Association rules between medicine and syndrome showed that symptoms of lack of stomach Yin commonly used Radix Paeoniae Alba,Caulis Dendrobii,Radix Ophiopogonis,Ebony,etc;syndrome of the weakness of the spleen and the stomach commonly used Atractylodes,Dangshen,and Poria Cocos;syndrome of damp heat in the spleen and the stomach commonly used Chinese Goldthread,Pinellia,Atractylodes,Spreading Hedyotis Herb,etc.Through cluster analysis,drugs with a higher frequency were classified into 6 types.The core drugs were composed of 32 Chinese herbs through complex network analysis.Conclusion It could be found that the clinical symptoms of the disease were complex and varied,intermingled deficiency and excess.Therapeutic principles and methods included nourishing Yin relieving spasms,invigorating the spleen and soothing the liver,heat-clearing and damp-drying,and benefiting Qi for activating blood circulation,etc.Prescriptions used included Shaoyao Gancao decoction,Sijunzi decoction,Banxia Xiexin decoction,and modification according to symptoms.

StomachacheChronic atrophic gastritisData mining

段园志、王微、王韶华、唐旭东

展开 >

北京中西医结合医院,北京 100038

中国中医科学院,北京 100700

胃痛 慢性萎缩性胃炎 数据挖掘

中国中医科学院科技创新工程重大攻关项目

CI2021A01004

2024

中国中医基础医学杂志
中国中医研究院基础理论研究所

中国中医基础医学杂志

CSTPCD
影响因子:0.779
ISSN:1006-3250
年,卷(期):2024.30(5)
  • 24