Effects of Modified Linggui Zhugan Decoction on TGF-β1,TNF-α,NT-proBNP and Ventricular Remodeling in Patients with Chronic Heart Failure of Yang Deficiency and Water Stagnation Syndrome
Objective To investigate the clinical efficacy of modified Linggui Zhugan decoction on TGF-β1,TNF-α,NT-proBNP and ventricular remodeling in patients with chronic heart failure of Yang deficiency and water stagnation syndrome.Methods Ninety-eight patients with chronic heart failure with Yang deficiency and water stagnation admitted to the Lu'an Hospital of traditional Chinese medicine from December 2017 to November 2020 were included in this study and randomly divided into two groups of 49 cases each.The patients from the control group were conventionally treated with western medicine,and the patients from the observation group were treated combined with modified Linggui Zhugan decoction on the basis of the control group(P<0.05).Cardiac function,tumor necrosis factor-α(TNF-α)and transforming growth factor-β1(TGF-β1)were measured after 6 months of treatment.TGF-β1,homocysteine(Hcy),amino-terminal brain sodium minogen(NT-proBNP)levels,and the clinical efficacy were compared.Results After treatment,all the indexes of the two groups were improved compared with those before treatment(P<0.05).The serum TNF-α,TGF-β1,Hcy,NT-proBNP levels,left ventricular end diastolic diameter,internal diameter of late left ventricular contraction and total TCM symptom score in observation group after treatment were lower than those in the control group(P<0.05).The left ventricular ejection fraction,6-minute walk distance and total effective rate of the observation group were higher than those of the control group(P<0.05).Conclusion Modified Linggui Zhugan decoction is known to attenuate inflammatory response,prevent ventricular remodeling,and improve clinical efficacy in chronic heart failure patients with Yang deficiency and water stagnation syndrome.
Modified Linggui Zhugan decoctionChronic heart failureYang deficiency and water stagnation syndromeVentricular remodelingCardiac functionFibrosis