Analysis of the Characteristics of Real World Clinical Drug Combination in 3 610 Patients with Jaundice Treated with Yinzhihuang Granules
Objective Directional data mining was carried out for the real world,and the clinical scheme characteristics of Yinzhihuang granules in the treatment of jaundice were analyzed to explore the combined medication scheme of Yinzhihuang granules in the treatment of jaundice.Methods The personal,hospitalization and drug use of 3 610 patients with jaundice treated with Yinzhihuang granules were extracted from 15 hospital information systems(HIS)in the real world.After standardizing the data,the combined drug scheme of Yinzhihuang granules in the treatment of jaundice was obtained by association rule data mining.Results The 3 610 patients of each age had the onset,which largest proportion 45-65 years old(1 242 cases,34.40%)and were more men than women.Combined medication:Yinzhihuang granules mainly use with Chinese and western medicine thymopeptide,dexamethasone,glycyrrhizic acid,phenobarbital,omeprazole,bupleurum injection,Ganmao Qingre granules,Kuhuang injection,Kangfuxin solution,Jiehe pills,drug type for western medicine antibacterial,hepatobiliary disease treatment,immune promotion,Chinese medicine diaphoretic recipes,heat clearing agent,forming agent.Common general jaundice treatment regimen:Yinzhihuang granules+Kuhuang injection+ glycyrrhizic acid,Yinzhihuang granules+glycyrrhizic acid+thymopeptide+Kuhuang injection.Collaborative treatment of jaundice caused by anti-tuberculosis drug-related liver damage:Yinzhihuang granules+Jiehe pills+Kangfuxin solution+ ethambutol,Yinzhihuang granules+pyrazinamide+rifampicin+ethambutol+Kangfuxin solution.Common drug types of joint program:Yinzhihuang granules+heat clearing agent+liver and bile disease treatment drugs,Yinzhihuang granules+ liver,biliary disease treatment drugs+immune promotion drugs+antibacterial drugs+heat clearing agent.Yinzhihuang granules+diaphoretic recipes+heat clearing agent+antibacterial drugs.Yinzhihuang granules+forming agent+diaphoretic recipes+heat clearing agent+antibacterial drugs.Conclusion For treating general jaundice,the clinical treatment scheme often used is Yinzhihuang granules with Kuhuang injection+glycyrrhizic acid and Yinzhihuang granules with Kuhuang injection+glycyrrhizic acid+thymopeptide;for jaundice caused by long-term use of anti-tuberculosis drugs,the commonly used treatment scheme is Yinzhihuang granules combined with Jiehe pills + Kangfuxin solution + ethambutol and Yinzhihuang granules combined with pyrazinamide+rifampin+ethambutol+Kangfuxin solution.
Real worldYinzhihuang granulesJaundiceCombination medicationHIS
NETL
NSTL
万方数据
