首页|基于中医时间医学探讨昼夜节律对双相情感障碍的影响

基于中医时间医学探讨昼夜节律对双相情感障碍的影响

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双相情感障碍是一种常见的精神障碍类疾病,其典型表现为生物节律紊乱.研究发现,双相情感障碍与生物节律紊乱二者互为因果,其中以严重的昼夜节律紊乱最为突出.中医时间医学以"天人相应"和"阴阳盛衰变化"为理论核心,强调四季昼夜变化对人体生理及病理的影响,故昼夜节律紊乱对双相情感障碍的发生、治疗及转归具有重要意义.本文将"昼夜节律"理论与现代医学生物节律中的褪黑素分泌水平、下丘脑-垂体-肾上腺轴相结合,探讨"昼夜节律"在双相情感障碍中的生理作用及其在不同疾病阶段的病理变化,旨在为临床治疗双相情感障碍提供新的诊疗思路.
Exploration of the Impact of Circadian Rhythm on Bipolar Disorder Based on Time Medicine of Traditional Chinese Medicine
Bipolar disorder is a common mental disorder,typically characterized by biological rhythm disorders.Research has found that bipolar disorder and biological rhythm disorder are mutually causal,with severe circadian rhythm disorder being the most prominent.Traditional Chinese medicine,based on the theoretical core of"correspondence between human body and natural environment"and"changes in the rise and fall of Yin and Yang",emphasizes the impact of changes in the day and night of the four seasons on the physiological and pathological aspects of the human body.Therefore,circadian rhythm disorders are of great significance for the occurrence,treatment,and prognosis of bipolar disorder.This article combines the theory of"circadian rhythm"with the secretion levels of melatonin and the hypothalamic-pituitary-adrenal axis in modern medical biological rhythms to explore the physiological role of"circadian rhythm"in bipolar disorder and its pathological changes in different disease stages,aiming to provide new diagnostic and therapeutic ideas for clinical treatment of bipolar disorder.

Bipolar disorderTime medicine of traditional Chinese medicineCircadian rhythmMelatoninHypothalamic-pituitary-adrenal axis

于明直、钱越、李宇盾、刘玥芸、陈家旭

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北京中医药大学中医学院,北京 100029

双相情感障碍 中医时间医学 昼夜节律 褪黑素 下丘脑-垂体-肾上腺轴

国家自然科学基金面上项目

82174278

2024

中国中医基础医学杂志
中国中医研究院基础理论研究所

中国中医基础医学杂志

CSTPCD
影响因子:0.779
ISSN:1006-3250
年,卷(期):2024.30(6)
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