Experimental Studies on Effect of Yizhi Drink on Learning and Memory Ability of Vascular Dementia Rats and Protection on Hippocampal Neuron
Objective:To observe the effects of Yizhi drink on learning and memory ability and the ultr structure of hippocampal neuron in vascular dementia rats.Methods:60 SD rats were randomly divided into sham operation group,model group,Yizhi drink group,piracetam (positive) group,the bilateral common carotid artery of rats repeatedly occlusion and recanalization,and sodium nitroprusside intraperitoneal injection methods for reducing blood pressure were applied to copy VD model.Using Morris water maze test in rats to determined the learning and memory ability; electron microscopy to observe histological changes of hippocam pal neuron in VD rats.Results:Yizhi drink can obviously shorten the escape time to plate and increase the number of passing through in VD rats,reduce the injury of hippocampal neurons.Conclusion:Yizhi drink can improve the learning and memory ability,and protect hippocampal neurons from injury.
vascular dementiaYizhi drinklearning and memory abilityhippocampal neuron
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维普
