Effects of Tiaopi Zengshi Granule(调脾增食颗粒)on Plasma β-EP and CCK-8 Levels in Juvenile Anorexia Rats
Objective:To investigate the effects of Tiaopi Zengshi Granule on plasma β-EP and CCK-8 levels of juvenile anorexia rats.Methods:60 young SD rats were randomly divided into 6 groups:normal control group,model control group,Tiaopi Zengshi Granule high,middle and low dose groups and positive control group with 10 rats in each group.Except the normal control group,all the other groups were fed with special high-protein and high-fat diet for one week to establish the models of anorexia.The normal group and the model group were given distilled water,and the high,middle and low dose groups of Tiaopi Zengshi Granule were given Tiaopi Zengshi Granule 33.86,16.93,8.47 g/(kg·d),positive group was given Jianwei Xiaoshi Tablet 0.675 g/(kg·d),all were intragastric administration for 4 weeks,food consumption of each group rats were recorded,the contents of plasma β-EP and CCK-8 in rat were determined by radioimmunoassay.Results:The food con-sumption of Tiaopi Zengshi Granule middle and high dose groups at the 3rd and 4th week was significantly higher than that of model control group(P<0.05,P<0.01).The contents of plasma β-EP in Tiaopi Zengshi Gra-nule middle and high dose groups were significantly higher than that in model control group(P<0.05,P<0.01),The content of plasma CCK-8 in Tiaopi Zengshi Granule middle and high dose groups was significantly lower than those in model control group(P<0.05,P<0.01).Conclusion:Tiaopi Zengshi Granule can regu-late the secretion and release of plasma β-EP and CCK-8 in anorexia rats.
Tiaopi Zengshi Granuleanorexiafood consumptionβ-EPCCK-8juvenile rat