Effects of Shugan Jianpi Granules(疏肝健脾颗粒)on Expressions of Fas and FasL in Precancerous Lesions Tissue of Breast Cancer in Rats
Objective:To investigate the effects of Shugan Jianpi Granules on expressions of Fas and FasL in precancerous lesions tissue of breast cancer in rats,and to analyze the mechanism of Shugan Jianpi Granules blocking the development of precancerous lesions of breast cancer.Methods:A total of 90 SD rats were randomly divided into 6 groups:healthy control group,model group,Tamoxifen group,and low,medium and high dose groups of Shugan Jianpi Granules.The models of breast cancer precancerous lesions which were induced by estrogen and progesterone combined with DMBA,each group was respectively given saline,Tamoxifen,and different dose Shu-gan Jianpi Granules for 60 days,the histopathology and Fas,FasL expressions were determined.Results:The rate of precancerous lesions of the model group rats was69.2%,The incidence of precancerous lesions in Shu-gan Jianpi Granules groups and the Tamoxifen group were lower than that in the model group(P<0.01),and some of model group and low,medium dose group of Shugan Jianpi Granules developed invasive cancer in the breast tissue.The expression of Fas protein in the mammary tissue of the rats in the normal control group was higher,and the expression of FasL protein was higher in the mammary tissue of the rats in the model group.Both Shuganjianpi Granules and Tamoxifen could increase the expression of Fas and decrease the expression of FasL protein.The effects were significantly different from those of the model group(P<0.05 or P<0.01).Conclu-sion:Shugan Jianpi Granules could significantly reduce the incidence of DMBA-induced precancerous lesions in rat breast cancer,and the possible mechanism was to intervene the expressions of Fas and FasL in precance-rous lesions of breast cancer.
breast cancerprecancerous lesionsShugan Jianpi GranulesTamoxifenFasFasLrat
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