Clinical Observation on Effect of Chaiyu Qinggan Decoction(柴郁清肝汤)in Treatment of NAFLD Patients with Liver Stagnation and Spleen Deficiency Syndrome and Its Effects on Th17/Treg,Inflammatory Factors
Objective:To observe the clinical effect of Chaiyu Qinggan Decoction on nonalcoholic fatty liver disease(NAFLD)patients with liver stagnation and spleen deficiency syndrome and its effects on Th17/Treg in peripheral blood and serum inflammatory factors.Methods:60 patients with NAFLD were randomly divided into observation group(30 cases)and control group(30 cases).The observation group was treated with Chaiyu Qinggan Decoction,and the control group was treated with Vitamin E soft capsule,they were treated for 8 weeks,the curative effect was evaluated,The liver function,blood lipid,inflammatory factors(IL-17,IL-22)and the percentage of Th17 and Treg in peripheral blood T lymphocytes were observed before and after treatment in the two groups.Results:After treatment for 8 weeks,16 cases were markedly effective and 12 cases were effec-tive in the observation group,and 8 cases were markedly effective and 13 cases were effective in the control group,the difference of effect between the two groups was statistically significant(P<0.05).Compared with be-fore treatment,ALT,AST,GGT,ALP,TC,TG,LDL-C,Th17,IL-17 and IL-22 in the two groups were significantly decreased,Treg was significantly increased,and the difference was statistically significant(P<0.05).The effects of observation group were significantly better than those in the control group,and the diffe-rences were statistically significant(P<0.05).Conclusion:Chaiyu Qinggan Decoction can effectively treat NAFLD patients,improve liver function and blood lipids,regulating the balance of Th17/Treg and the se-cretion of related inflammatory factors is one of the mechanisms.
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