Effects of Shengyang Yiwei Decoction(升阳益胃汤)on Pathological Changes and Expressions of p38,ERK Protein in Gastric Tissues of Mice with Chronic Gastritis
Objective:To explore the effects of Shengyang Yiwei Decoction on pathological changes of gas-tric mucosa and expressions of p38、ERK protein in chronic gastritis mouse.Methods:40 healthy male mice were divided into normal group,model group,Shengyang Yiwei Decoction group and Western medicine group with each 10 mice.The model of chronic gastritis was established by gavage 2 mL of 2%sodium salicylate every day for 8 weeks,each group was given corresponding medicine by gavage for 30 days,and gastric specimens were taken for HE staining,gastric tissues were observed with light microscope.The expressions of gastric tissues p38 and ERK protein in mice was measured by immunofluorwescence Results:No inflammatory pathological changes were found in the gastric mucosa of normal mice;In the model group,gastric mucosa inflammation was ob-served;The degree of inflammation in Western medicine group was reduced;The degree of inflammation in Shengyang Yiwei Decoction group was significantly reduced.Immunofluorwescence detection results showed that the expressions of gastric tissues p38 and ERK protein in model group were higher than those of normal group,p38 and ERK protein expressions of Shengyang Yiwei Decoction group were lower than those of model group,but that were higher than those of normal group.Conclusion:Shengyang Yiwei Decoction can reduce the pathological changes of mucosa in chronic gastritis mice by regulating p38 and ERK protein expressions.
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