Effects of Jianpi Ningshen Granule(健脾宁神颗粒)on Monoamine Neurotransmitter in Brain of Mice with Tic Disorder
Objective:To study the effect of Jianpi Ningshen Granule on the brain monoamine neurotrans-mitter in mice with tic disorder,and to explore the possible mechanism of Jianpi Ningshen Granule.Methods:60 male ICR mice,except 10 as the normal control group,other groups were established tic disorder model.Af-ter successful modeling,the rats were randomly divided into model control group,high,middle and low dose groups of Jianpi Ningshen Granule,and positive control group of Tiapride,the levels of dopamine(DA),5-hydroxytryptamine(5-HT)and noradrenaline(NE)were measured by enzyme-linked immunosorbent assay(ELISA).Results:Compared with the normal control group,the content of 5-HT in the brain of the model control group increased significantly(P＜0.05),while the content of DA and NE decreased significantly(P＜0.05,P＜0.01).Compared with the model control group,the content of 5-HT in the brain tissue of the high-dose group was significantly decreased(P＜0.05),while the contents of DA and NE were significantly in-creased(P＜0.05).Conclusion:To regulate brain monoamine eurotransmitter DA,5-HT and NE levels was one of the mechanism that Jianpi Ningshen Granule on tic disorder.
万方数据
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