Curative Effects of Yiqi Jianpi Decoction(益气健脾汤)in Treatment of Incipient Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease and Influence on Intestinal Microbiota Diversity
Objective:To confirm the therapeutic effect of Yiqi Jianpi Decoction in treating incipient type 2 diabetes accompanied by non-alcoholic fatty liver disease and its influence on intestinal microbiota diversity.Methods:68 patients with spleen deficiency and dampness trapped syndrome with incipient type 2 diabetes me-llitus and non-alcoholic fatty liver disease were divided to the control group and the observation group randomly,with 34 patients in each group.The control group was given Pioglitazone metformin tablets,the observation group was treated with Yiqi Jianpi Decoction based on the control group for oral treatment,and the course of treatment for both groups was 12 weeks.The changes in TCM syndrome scores,biochemical indexes(FPG,FINS,HBA1c,AST,ALT,GGT),insulin resistance index were observed respectively before and after treatment,and their cura-tive effect was evaluated.16S rRNA high-throughput sequencing was used to detect the intestinal microbiota di-versity in each group.Results:The clinical efficacy of the observation group was superior to that of the control group,and there was significant difference(P＜0.05).To compare with the control group,the levels of FPG,FINS,HBA1c,AST,ALT,GGT,and HOMA-IR in observation group were significantly reduced after treat-ment,and these differences were found to be significant(P＜0.05).Additionally,to compare with the control group,the Simpon index was significantly lower and Ace,Chaol,and Shannon index were greater for the obser-vation group,and all of the differences were found to be significant(P＜0.05).Conclusion:Yiqi Jianpi Decoc-tion can improve insulin resistance of patients with incipient type 2 diabetes mellitus with non-alcoholic fatty liver disease,lower blood glucose and protect liver func-tion,restoring the intestinal microbiota diversity in one of its mechanism.
non-alcoholic fatty liver diseaseincipient type 2 diabetesYiqi Jianpi Decoctionintestinal mi-crobiotaspleen deficiency and dampness trapped syndromeliver functionblood glucoseinsulin resistance
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