Effect of Shenqi Dihuang Decoction(参芪地黄汤)Combined with Hydroxychloroquine in Treatment of IgA Nephropathy and Effects on Th1/Th2
Objective:To evaluate the clinical efficacy of combining Shenqi Dihuang Decoction with Hydroxychloroquine(HCQ)in treatment of Qi-Yin deficiency type IgA nephropathy(IgAN)and its impact on Thl/Th2 balance.Methods:A total of 42 IgA nephropathy patients with Qi and Yin deficiency were randomly divided into observation group and control group,21 cases in each group.The control group was given oral HCQ,and the observation group was treated with Shenqi Dihuang Decoction on the basis of the control group.The clinical efficacy,TCM symptoms score,biochemical indexes[Serum creatinine(SCr),albumin(Alb)],24-hour urinary protein quantitation(24 h-uPQ),cytokines[interferon-γ(INF-γ),interleukin-4(IL-4),interleukin-10(IL-10)]and helper T lymphocytes(Th)were compared between the two groups.Re-sults:The total effective rate of the observation group(81.0％)was found to be significantly higher than that of the control group(57.1％)(P＜0.05).Following treatment,both groups exhibited a decrease in TCM symp-tom scores related to shortness of breath,fatigue,night sweats,waist and knee soreness,as well as feverish sen-sation in the palms and soles;however,these reductions were more pronounced in the observation group com-pared to the control group(P＜0.05).Additionally,post-treatment levels of SCr,24 h-uPQ,INF-γ,Th1 and Th1/Th2 were lower in both groups compared to pre-treatment levels;nevertheless,these reductions were significantly greater in the observation group when compared with the control group(P＜0.05).Furthermore,post-treatment levels of Alb,IL-4,IL-10 and Th2 showed an increase in both groups relative to pre-treat-ment levels;notably though,the observation group demonstrated significantly higher increases compared to the control group(P＜0.05).Conclusion:Shenqi Dihuang Decoction combined with HCQ can significantly im-prove the clinical symptoms of IgAN patients with Qi and Yin deficiency,effectively control urinary protein,pro-tect renal function,correct immune dysfunction and reduce micro-inflammatory state,and has a definite clinical effect.
Shenqi Dihuang DecoctionHydroxychloroquineQi and Yin deficiency typeIgA nephropathyINF-γIL-4IL-10Th1/Th2
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