Clinical Study on Curative Effect of Non-Alcoholic Fatty Liver with Phlegm Turbidity Resistance Syndrome Treated with Zexie Decoction(泽泻汤)and Erchen Decoction(二陈汤)
Clinical Study on Curative Effect of Non-Alcoholic Fatty Liver with Phlegm Turbidity Resistance Syndrome Treated with Zexie Decoction(泽泻汤)and Erchen Decoction(二陈汤)
Objective:To observe the curative effect of Zexie Decoction combined with Erchen Decoction in the treatment of patients with non-alcoholic fatty liver disease(NAFLD)with phlegm turbidity resistance syn-drome and its effects on human cytokeratin 18(CK-18)and transforming growth factor-β 1(TGF-β1).Methods:84 patients with NAFLD of phlegm turbidity resistance syndrome recruited were randomly divided into an observation group and a control group,with 42 patients in each group.The control group was treated with Po-lyene phosphatidylcholine capsules,while the observation group was treated with Zexie Decoction and Erchen De-coction modified.The treatment course for both groups was 8 weeks.Compare the clinical efficacy,TCM syn-drome scores before and after treatment,controlled attenuation parameters(CAP)of the liver,liver function in-dexes,blood lipid,as well as CK-18 and TGF-β1 levels between two groups.Results:After 8 weeks of treat-ment,he total effective rate of the observation group was 83.33%,which was higher than the 64.29%of the con-trol group(P<0.05);The TCM syndrome scores of both groups were significantly reduced compared to before treatment(P<0.01),and the syndrome scores of observation group was lower than that the control group(P<0.01);The CAP values of both groups were significantly reduced compared to before treatment(P<0.01),and the CAP of observation group was lower than that of the control group(P<0.01);The levels of ALT,AST,GGT,TC,and TG in two groups were significantly reduced compared to before treatment(P<0.01),and the those in observation group were lower than those of the control group(P<0.01);The levels of CK-18 and TGF-β1 in the two groups were significantly reduced compared to before treatment(P<0.01),and the levels of CK-18 and TGF-β 1 of the observation group were lower than those of the control group(P<0.01).Conclusion:The combination of Zexie Decoction and Erchen Decoction has a significant effect on the treatment of patients with NAFLD of phlegm turbidity resistance syndrome.It can significantly improve phlegm turbidity resistance syn-drome,improve liver function and blood lipid levels,reduce CAP values and CK-18,TGF-β1 levels.
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