首页|靶向合成改善病情抗风湿药在类风湿关节炎中的应用评价

靶向合成改善病情抗风湿药在类风湿关节炎中的应用评价

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近年来,新型抗类风湿关节炎药不断涌现,包括生物类改善病情抗风湿药(bDMARDs)和靶向合成改善病情抗风湿药(tsDMARDs).其中,tsDMARDs因其良好的临床疗效、口服制剂的便利性及可控的不良反应而在临床广泛应用.本文就tsDMARDs的作用机制、临床研究、不良反应、上市情况等进行综述,以期为临床应用提供参考.
Application Evaluation of Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs in Rheumatoid Arthritis
In recent years,numerous novel drugs for rheumatoid arthritis have been developed,including biological disease-modifying anti-rheumatic drugs(bDMARDs)and targeted synthetic disease-modifying anti-rheumatic drugs(tsDMARDs).Among them,tsDMARDs are widely used in clinic practice due to their favorable clinical efficacy,oral administration convenience and managable adverse reactions.This paper reviews the mechanism of action,clinical study,adverse reactions and listing status of tsDMARDs,in order to provide reference for clinical application.

rheumatoid arthritistargeted synthetic disease-modifying anti-rheumatic drugsclinical studymechanism of actionadverse drug reaction

张淼淼、李婷、张田、王洋、金鹏飞、张亚同

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北京医院药学部,国家老年医学中心,中国医学科学院老年医学研究院,北京市药物临床风险与个体化应用评价重点实验室(北京医院),北京 100730

类风湿关节炎 靶向合成改善病情抗风湿药 临床研究 作用机制 药品不良反应

2024

中国合理用药探索
中国执业药师协会

中国合理用药探索

影响因子:0.62
ISSN:2096-3327
年,卷(期):2024.21(1)
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