Effect of Shugan Liqi Yangxue Decoction in Combination with Citalopram Hydrobromide on Sleep Quality and Neurotransmitter in Elderly Patients with Insomnia After Stroke and Depression
Objective:To observe the efficacy and effects on sleep quality and neurotransmitters of Shugan Liqi Yangxue decoction combined with citalopram hydrobromide in the treatment of post-stroke insomnia with depression in elderly patients.Methods:A total of 114 elderly patients with post-stroke insomnia and depression admitted to a hospital from May 2021 to February 2023 were selected for the study.They were divided into the control group and the observation group using the randomized numerical table method,with 57 cases in each group.The control group received citalopram hydrobromide,and the observation group received Shugan Liqi Yangxue decoction in addition to citalopram hydrobromide.The levels of neurotransmitters[5-hydroxytryptamine(5-HT),substance P(SP),glycine,and γ-aminobutyric acid]were detected in both groups.Additionally,the National Institute of Health stroke scale(NIHSS)scores,Pittsburgh sleep quality index(PSQI)scores,traditional Chinese medicine(TCM)symptom scores,and Hamilton depression scale(HAMD)scores were assessed in both groups,activity of daily living scale(ADL)scores.The total effective rate of clinical treatment was compared between the two groups and the occurrence of adverse events during treatment was recorded for both groups.Results:After treatment,5-HT,glycine and γ-aminobutyric acid were higher in both groups compared with before treatment.Additionally,the levels of each index in the observation group was higher than that in the control group(P＜0.05);the SP of both groups were lower than before treatment,and the observation group was lower than the control group(P＜0.05);the NIHSS score,PSQI score,HAMD score,and TCM symptom score of both groups were lower than before treatment,and the PSQI score,HAMD score,and TCM symptom score of the observation group were lower than those of the control group(P＜0.05);the ADL scores of both groups were higher than before treatment,and the observation group was higher than the control group(P＜0.05).After treatment,the total effective rate of clinical treatment in the observation group(91.23%)was higher than that in the control group(77.19%,P＜0.05).There was no statistical difference in the total incidence of adverse reactions between the two treatment groups.Conclusion:Shugan Liqi Yangxue decoction combined with citalopram hydrobromide can effectively improve the symptoms of depression and insomnia,improve the quality of sleep,regulate the expression of neurotransmitters,and improve the therapeutic efficacy of elderly patients with post-stroke insomnia with depression,and does not increase the risk of adverse reactions.
万方数据
维普
