With the acceleration of modern life,the prevalence of insomnia is gradually increasing,which can significantly impact individuals'work and life.Currently,the primary medications used to alleviate insomnia symptoms in clinical practice are sedative-hypnotic drugs.As a new generation of anti-insomnia drugs,orexin receptor antagonists can increase the duration of each stage of sleep,weaken the arousal signal,thus inhibiting wakefulness rather than inducing sedation,and effectively avoiding some disadvantages of traditional sedative-hypnotic drugs.This article provides a review of the research progress of the efficacy and safety of three prominent drugs,suvorexant,lemborexant,and daridorexant,as orexin receptor antagonists,aiming to provide reference for the treatment of insomnia.
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