Research Progress of Anti-Insomnia Drugs of Orexin Receptor Antagonist
With the acceleration of modern life,the prevalence of insomnia is gradually increasing,which can significantly impact individuals'work and life.Currently,the primary medications used to alleviate insomnia symptoms in clinical practice are sedative-hypnotic drugs.As a new generation of anti-insomnia drugs,orexin receptor antagonists can increase the duration of each stage of sleep,weaken the arousal signal,thus inhibiting wakefulness rather than inducing sedation,and effectively avoiding some disadvantages of traditional sedative-hypnotic drugs.This article provides a review of the research progress of the efficacy and safety of three prominent drugs,suvorexant,lemborexant,and daridorexant,as orexin receptor antagonists,aiming to provide reference for the treatment of insomnia.
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