中国合理用药探索2024,Vol.21Issue(2) :41-45.DOI:10.3969/j.issn.2096-3327.2024.02.007

1例注射用阿替普酶致谵妄病例的治疗分析

Case Report of One Patient with Delirium Caused by Alteplase for Injection

谷晓云 袁明辉 张宁 王茜
中国合理用药探索2024,Vol.21Issue(2) :41-45.DOI:10.3969/j.issn.2096-3327.2024.02.007

1例注射用阿替普酶致谵妄病例的治疗分析

Case Report of One Patient with Delirium Caused by Alteplase for Injection

谷晓云 1袁明辉 1张宁 2王茜1
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作者信息

  • 1. 威海市食品药品检验检测研究院,威海 264200
  • 2. 荣成市石岛人民医院,荣成 264300
  • 折叠

摘要

目的:探讨注射用阿替普酶致谵妄的发生情况,以提高临床使用的合理性和安全性.方法:回顾性分析1例注射用阿替普酶致谵妄患者的诊疗过程,并结合文献检索,探讨注射用阿替普酶与谵妄的关联性及应对措施.结果:根据患者的临床表现及关联性评价,判定注射用阿替普酶与谵妄的关联性评价结果为"很可能有关".患者经停药治疗后,其谵妄症状消失.结论:临床在使用注射用阿替普酶前,应评估患者过敏史、用药史等基本情况,降低谵妄的发生率或减轻谵妄的严重程度,以保障患者用药安全.

Abstract

Objective:To investigate the occurrence of delirium induced by alteplase for injection and to improve the rationality and safety of its clinical use.Methods:The diagnosis and treatment process of a patient with delirium induced by alteplase for injection was retrospectively analyzed.The correlation between alteplase for injection and delirium,as well as the countermeasures,were discussed.Results:Based on the clinical manifestation and correlation evaluation of the patient,the correlation evaluation result of alteplase for injection and delirium was judged as"probable".The patient's delirium disappeared after discontinuation of medication.Conclusion:Prior to administering alteplase for injection,patients'allergy history and medication history should be evaluated to reduce the incidence or severity of delirium,thereby ensuring the medication safety.

关键词

阿替普酶/谵妄/药品不良反应/病例报告/精神异常

Key words

alteplase/delirium/adverse drug reactions/case report/psychosis

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出版年

2024
中国合理用药探索
中国执业药师协会

中国合理用药探索

影响因子:0.62
ISSN:2096-3327
参考文献量22
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