One Case of Immune-Related Oral Mucositis and Skeletal Muscle Injury Induced by Camrelizumab
Objective:To investigate the clinical characteristics of camrelizumab-induced oral mucositis with skeletal muscle injury in order to enhance the monitoring of camrelizumab administration and promote its safeclinical use.Methods:A 85-year-old female with thyroid cancer,severe oral mucositis and skeletal muscle injury induced by camrelizumab was included in the analysis.Results:The patient received camrelizumab 200 mg ivgtt for 21 days.On the 17th day after the second cycle,the patient complained of pain in neck,shoulder and back muscles.Blood myoglobin(MYO)was found to be elevated.Before the treatment,MYO,cardiac troponin T(cTnT),and creatine kinase isoenzymes(CK-MB)were found to be normal.After the third cycle on the 15th day,MYO remained high,while cTnT and CK-MB were normal.The patient's face was flushed and severe oral mucosal inflammation occurred,with obvious pain and difficulty when eating.Medications such as hydrocortisone were given as symptomatic support for treatment.The patient's facial flushing and oral mucosal inflammation were significantly reduced after receiving treatment with a liquid diet.After discharge,the patient did not receive any further treatment with camrelizumab,and did not experience muscle pain in the neck,shoulder,or back,as well as oral mucosal inflammation.Conclusion:During the clinical application of camrelizumab,attention should be paid to observing the oral mucosa condition of patients and testing the blood MYO value.Any abnormalities should be identified in a timely manner and treated according to the severity of adverse events.In severe cases,camrelizumab should be discontinued.
camrelizumabskeletal muscle injuryoral mucositisimmune-related adverse eventsthyroid cancer
万方数据
维普
