Analysis of the Efficacy of Deslanoside Combined with Amiodarone in the Treatment of Patients with Acute Heart Failure Complicated with Arrythenia
Objective:To investigate the efficacy and safety of deslanoside combined with amiodarone in the treatment of acute heart failure(AHF)complicated with tachyarrhythmia,as well as the influence on cardiac function and vascular endothelial function.Methods:From January 2020 to January 2023,a total of 150 patients diagnosed with AHF complicated with tachyarrhythmia admitted to a hospital were include for the study.They were divided into the deslanoside group and the combination group by random number table method,with 75 cases in each group.Upon admission,all patients were given standard care including oxygen therapy,cardiotonic medication,diuretic,and ECG monitoring based on their clinical condition.Patients in the deslanoside group received intravenous deslanoside injection,while those in the combination group received amiodarone hydrochloride injection on the basis of the deslanoside group.Both groups were treated for 48 hours.The study compared the clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular posterior wall thickness(LVPWT)],vascular endothelial function indexes[endothelin-1(ET-1),flow-mediated dilation(FMD),von Willebrand factor(vWF)]and occurrence of adverse reactions between the two groups.Results:After treatment,the total effective rate in the combination group(96.00%)was higher than that in the deslanoside group(86.67%,P<0.05).The LVEF increased in both groups(P<0.05),with a higher increase observed in the combination group compared to the deslanoside group(P<0.05).The LVEDD and LVPWT decreased in both groups(P<0.05),with a greater decrease observed in the combination group compared to the deslanoside group(P<0.05).The serum levels of ET-1 and vWF decreased in both groups(P<0.05),with a greater decrease observed in the combination group compared to the deslanoside group(P<0.05).Additionally,FMD increased in both groups(P<0.05),with a higher increase observed in the combination group compared to the deslanoside group(P<0.05).No significant difference was observed in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion:The deslanoside combined with amiodarone in the treatment of AHF complicated with tachyarrhythmia has shown significant clinical efficacy.It can effectively promote the recovery of cardiac function and improve vascular endothelial dysfunction in patients without increasing the risk of adverse reactions.
deslanosideamiodaroneacute heart failuretachyarrhythmiacardiac functionvascular endothelial function
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维普
